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A simple, automated method of seizure detection in mouse models of temporal lobe epilepsy.
- Source :
-
Epilepsy research [Epilepsy Res] 2023 Dec; Vol. 198, pp. 107256. Date of Electronic Publication: 2023 Nov 08. - Publication Year :
- 2023
-
Abstract
- The lack of preventive and disease modifying therapies for temporal lobe epilepsy (TLE) is a major unmet medical need. Search for such therapies utilize mouse models and require detection of seizures in electroencephalography (EEG) recordings. The labor-intensive nature of reviewing EEGs spanning many weeks underscores the need for a method of automated detection. Here we report a simple automated method of detecting seizures in long term EEG recordings from electrodes implanted in the hippocampus in animal models of TLE. We utilize a 2-pronged approach that relies on the increase in power within the gamma band range (20-50hz) during the seizure followed by suppression of activity following the seizure (post-ictal suppression [PIS]). We demonstrate the utility of this method for detecting seizures in hippocampal and amygdala EEG recordings from multiple models of TLE.<br />Competing Interests: Conflict of interest None of the authors has any conflict of interest to disclose.<br /> (Copyright © 2023 Elsevier B.V. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1872-6844
- Volume :
- 198
- Database :
- MEDLINE
- Journal :
- Epilepsy research
- Publication Type :
- Academic Journal
- Accession number :
- 38000152
- Full Text :
- https://doi.org/10.1016/j.eplepsyres.2023.107256