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Polygenic risk of obesity and BMI trajectories over 36 years: A longitudinal study of adult Finnish twins.
- Source :
-
Obesity (Silver Spring, Md.) [Obesity (Silver Spring)] 2023 Dec; Vol. 31 (12), pp. 3086-3094. - Publication Year :
- 2023
-
Abstract
- Objective: This study investigated 36-year BMI trajectories in twins whose BMI in young adulthood was below, within, or above their genetically predicted BMI, with a focus on twin pairs with large intrapair BMI differences (within-pair ΔBMI ≥ 3 kg/m <superscript>2</superscript> ).<br />Methods: Together, 3227 like-sexed twin pairs (34% monozygotic) were examined at age ~30 years in 1975 and followed up in 1981, 1990, and 2011. An individual's observed BMI in 1975 was considered within (±2.0), below (<-2.0), or above (>+2.0) genetically predicted BMI, measured by a polygenic risk score of 996,919 single nucleotide polymorphisms.<br />Results: In monozygotic and dizygotic twin pairs with large intrapair BMI differences, the co-twin with a higher observed BMI in 1975 deviated above predicted BMI more frequently (~2/3) than the co-twin with a lower BMI deviated below prediction (~1/3). Individuals below, within, and above prediction in 1975 reached, respectively, normal weight, overweight, and obesity by 2011, with a mean BMI increase of 4.5 (95% CI: 4.3-4.8).<br />Conclusions: Categorizing BMI as below, within, or above polygenic risk score-predicted BMI helps identifying individuals who have been resistant or susceptible to weight gain. This may provide new insights into determinants and consequences of obesity.<br /> (© 2023 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society.)
Details
- Language :
- English
- ISSN :
- 1930-739X
- Volume :
- 31
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Obesity (Silver Spring, Md.)
- Publication Type :
- Academic Journal
- Accession number :
- 37987187
- Full Text :
- https://doi.org/10.1002/oby.23906