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Human Circovirus is not detected in plasma pools for fractionation.
- Source :
-
Transfusion [Transfusion] 2024 Jan; Vol. 64 (1), pp. 16-18. Date of Electronic Publication: 2023 Nov 19. - Publication Year :
- 2024
-
Abstract
- Background: Human Circovirus 1 and 2 were recently described in a French hepatitis case and in two Chinese drug users. Because of its small size and presumable high resistance to both inactivation and removal by nanofilters, such viruses-if determined to be even pathogenic-should be considered with respect to the safety of plasma derivatives. We, therefore, investigated the prevalence and titer of these viruses in plasma pools before fractionation.<br />Methods and Materials: We tested for the presence of Human Circovirus 1 and 2 by qPCR in 48 plasma pools derived from healthy donors from Europe, USA, and Japan, corresponding to more than 200,000 plasma donations.<br />Results: We did not detect the presence of Human Circovirus 1 and 2 in any of the plasma pools, with a limit of detection of 300-600 genome copies per mL of plasma.<br />Conclusions: These results indicate that high levels of circovirus are not widely prevalent in such donations.<br /> (© 2023 The Authors. Transfusion published by Wiley Periodicals LLC on behalf of AABB.)
- Subjects :
- Humans
Plasma
Europe
Japan
Circovirus genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1537-2995
- Volume :
- 64
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Transfusion
- Publication Type :
- Academic Journal
- Accession number :
- 37982366
- Full Text :
- https://doi.org/10.1111/trf.17604