A single locus determines praziquantel response in Schistosoma mansoni .

Authors :: Chevalier FD
Clec'h WL
Berriman M
Anderson TJC
Source :: BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 04. Date of Electronic Publication: 2023 Nov 04.
Publication Year :: 2023
Abstract: We previously performed a genome-wide association study (GWAS) to identify the genetic basis of praziquantel (PZQ) response in schistosomes, identifying two quantitative trait loci (QTL) situated on chromosome 2 and chromosome 3. We reanalyzed this GWAS using the latest (v10) genome assembly showing that a single locus on chromosome 3, rather than two independent loci, determines drug response. These results reveal that praziquantel response is monogenic and demonstrates the importance of high-quality genomic information.<br />Competing Interests: Competing interests: Authors declare that they have no competing interests.