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Dopamine agonist serum concentrations and impulse control disorders in Parkinson's disease.
- Source :
-
European journal of neurology [Eur J Neurol] 2024 Feb; Vol. 31 (2), pp. e16144. Date of Electronic Publication: 2023 Nov 13. - Publication Year :
- 2024
-
Abstract
- Background and Purpose: Impulse control disorders (ICDs) are common among Parkinson's disease patients using dopamine agonists. We wanted to determine whether ICD patients have higher dopamine agonist serum concentrations than those without any sign of ICD.<br />Methods: Patients who used either pramipexole or ropinirole depot once daily were screened for ICDs using the validated Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale. Those who scored above the cut-off for one or more of the four defined ICDs (gambling, compulsive sexual behavior, compulsive shopping, and binge-eating) were compared in a case-control study to patients who scored zero points (no evidence of ICD) on the same items. They were examined clinically and evaluated using relevant scales. Three blood samples were taken on the same day: before daily dose, and then 6 and 12 h later.<br />Results: Forty-six patients were included: 19 ICD-positive and 27 controls. Ropinirole serum concentrations 6 h after daily intake (C <subscript>max</subscript> ) were higher in the case group compared to the control group, as was the daily ropinirole dosage. No differences were observed in serum concentrations, dosage or total drug exposure for pramipexole. Disease duration and length of dopamine agonist treatment was significantly longer among ICD patients for ropinirole, but not for pramipexole.<br />Conclusions: The use of pramipexole may in itself confer high ICD risk, whereas ICDs among ropinirole users depend more on serum concentration and drug exposure. The pharmacokinetic properties of ropinirole make it challenging to predict its effects on patients, which supports the need for therapeutic drug monitoring to reduce risk of ICD.<br /> (© 2023 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.)
- Subjects :
- Humans
Dopamine Agonists adverse effects
Pramipexole therapeutic use
Case-Control Studies
Parkinson Disease complications
Parkinson Disease drug therapy
Parkinson Disease diagnosis
Disruptive, Impulse Control, and Conduct Disorders chemically induced
Disruptive, Impulse Control, and Conduct Disorders drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1468-1331
- Volume :
- 31
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- European journal of neurology
- Publication Type :
- Academic Journal
- Accession number :
- 37955562
- Full Text :
- https://doi.org/10.1111/ene.16144