Back to Search Start Over

Eugeniin improves cholesterol metabolism in HepG2 cells and Caco-2 cells.

Eugeniin improves cholesterol metabolism in HepG2 cells and Caco-2 cells.

Authors :
Ye Y
Takeuchi A
Kawaguchi Y
Matsuba S
Zhang N
Mijiti M
Banno A
Hiramatsu N
Okada T
Nagaoka S
Source :
Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2023 Dec 19; Vol. 88 (1), pp. 97-106.
Publication Year :
2023

Abstract

Considering the absence of prior studies on the cholesterol metabolism-improving effects of eugeniin, the present investigation aimed to explore the potential impact of eugeniin on cholesterol metabolism. This study sought to elucidate the molecular mechanisms involved in this process using HepG2 and Caco-2 cells treated with 5 µm eugeniin. The intracellular cholesterol levels in HepG2 and Caco-2 cells were significantly decreased in the 24-h eugeniin-treated group. The protein and messenger ribonucleic acid (mRNA) levels of the low-density lipoprotein receptor (LDLR) were increased, while 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase protein and mRNA levels were decreased in HepG2 cells 6 h of the eugeniin-treated group. Additionally, LDLR protein and mRNA levels were increased in HepG2 cells after 24 h of eugeniin treatment. In Caco-2, the protein and mRNA levels of ATP-binding cassette transporter 1 were increased after 24 h eugeniin treatment. This novel finding indicates that eugeniin improves cholesterol metabolism in human cell cultures.<br /> (© The Author(s) 2023. Published by Oxford University Press on behalf of Japan Society for Bioscience, Biotechnology, and Agrochemistry.)

Details

Language :
English
ISSN :
1347-6947
Volume :
88
Issue :
1
Database :
MEDLINE
Journal :
Bioscience, biotechnology, and biochemistry
Publication Type :
Academic Journal
Accession number :
37952102
Full Text :
https://doi.org/10.1093/bbb/zbad158