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Protocol digest of a randomized controlled adaptive Phase II/III trial of neoadjuvant chemotherapy for Japanese patients with oesophagogastric junction adenocarcinoma: Japan Clinical Oncology Group Study JCOG2203 (NEO-JPEG).
- Source :
-
Japanese journal of clinical oncology [Jpn J Clin Oncol] 2024 Feb 07; Vol. 54 (2), pp. 206-211. - Publication Year :
- 2024
-
Abstract
- Treatment strategies for oesophagogastric junction adenocarcinoma have not been standardized despite its poor prognosis due to differences in the incidence rates between Western countries and Asia. This randomized Phase II/III trial was initiated in June 2023 to determine which neoadjuvant chemotherapy regimen, docetaxel, oxaliplatin and S-1 or fluorouracil, oxaliplatin and docetaxel, is a more promising treatment in Phase II and confirm the superiority of neoadjuvant chemotherapy with docetaxel, oxaliplatin and S-1 or fluorouracil, oxaliplatin and docetaxel followed by surgery and postoperative chemotherapy over upfront surgery and postoperative chemotherapy in terms of overall survival in patients with Clinical Stage III or IVA oesophagogastric junction adenocarcinoma in Phase III. A total of 460 patients, including 150 patients in Phase II and 310 patients in Phase III, are planned to be enrolled from 85 hospitals in Japan over 5 years. This trial has been registered in the Japan Registry of Clinical Trials as jRCTs031230182 (https://jrct.niph.go.jp/latest-detail/jRCTs031230182).<br /> (© The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Subjects :
- Humans
Docetaxel therapeutic use
Oxaliplatin therapeutic use
Japan
Neoadjuvant Therapy methods
Treatment Outcome
Esophagogastric Junction pathology
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Fluorouracil therapeutic use
Randomized Controlled Trials as Topic
Clinical Trials, Phase II as Topic
Clinical Trials, Phase III as Topic
Stomach Neoplasms pathology
Esophageal Neoplasms pathology
Adenocarcinoma pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1465-3621
- Volume :
- 54
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Japanese journal of clinical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 37952093
- Full Text :
- https://doi.org/10.1093/jjco/hyad149