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D-aspartate in human brain.
- Source :
-
Journal of neurochemistry [J Neurochem] 1987 Feb; Vol. 48 (2), pp. 510-5. - Publication Year :
- 1987
-
Abstract
- The presence of the biologically uncommon D-aspartic acid (D-aspartate) in human brain white matter has been previously reported. The earlier study has now been expanded to include D/L-aspartate ratios from 67 normal brains. The data show that the D-aspartate content increases rapidly from 1 year to approximately 35 years of age, levels off in middle age, and then appears to decrease somewhat. The D-aspartate content in gray matter remains at a consistently low level (half of that found in white matter) throughout the human life span. Within the limitations of current analytical methods, there was no detectable difference in D/L-aspartate ratios in white and gray matter of brains with Alzheimer's disease and several other pathologies when compared with brains of normal subjects. However, the presence of a significant D-aspartate level in white matter during the adult life span may lead to changes in protein configuration related to dysfunctions associated with the aging brain.
Details
- Language :
- English
- ISSN :
- 0022-3042
- Volume :
- 48
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of neurochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 3794720
- Full Text :
- https://doi.org/10.1111/j.1471-4159.1987.tb04122.x