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The Cukurova score in the prediction of primary cytoreduction in ovarian cancer.
- Source :
-
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society [Int J Gynecol Cancer] 2024 Jan 05; Vol. 34 (1), pp. 122-130. Date of Electronic Publication: 2024 Jan 05. - Publication Year :
- 2024
-
Abstract
- Objective: Primary debulking surgery has been the preferred surgical route and is still considered a quality indicator for advanced ovarian cancer surgery. However, a significant number of patients are not amenable to upfront surgery. Neoadjuvant chemotherapy and interval debulking surgery may be the most suitable approach for this group. This study aimed to evaluate a novel score for prediction of the cytoreduction results at primary debulking surgery for ovarian cancer patients.<br />Methods: This observational prospective study was conducted at a tertiary gynecologic oncology center between December 2020 and August 2022. Presumed primary stage III-IV epithelial ovarian carcinoma cases were included. Borderline tumors, and metastatic or non-epithelial ovarian malignancies, were excluded. Based on imaging findings, points were assigned to each anticipated surgical procedure required for complete cytoreduction. The sum of these points was multiplied by the patient's Eastern Cooperative Oncology Group (ECOG) score, and thus, the Cukurova-clinic score was established. Furthermore, the required surgical procedures based on laparoscopic evaluation were recorded, and the score was readjusted and calculated to obtain the Cukurova score.<br />Results: One hundred and fourteen patients were included in the study. Primary debulking surgery was performed in 70% of cases. Among them, complete cytoreduction (Cukurova score ≤12) was obtained in 97.3% of cases. Complete cytoreduction was not achieved in cases with Cukurova score >12. The odds ratio of 90-day mortality was 13.4 for patients with Cukurova score >12, compared with those with Cukurova score ≤12.<br />Conclusion: The Cukurova score is a model for classifying advanced ovarian cancer patients who may be candidates for primary debulking surgery.<br />Competing Interests: Competing interests: None declared.<br /> (© IGCS and ESGO 2024. No commercial re-use. See rights and permissions. Published by BMJ.)
- Subjects :
- Humans
Female
Middle Aged
Prospective Studies
Aged
Adult
Neoplasm Staging
Aged, 80 and over
Cytoreduction Surgical Procedures methods
Ovarian Neoplasms surgery
Ovarian Neoplasms pathology
Carcinoma, Ovarian Epithelial surgery
Carcinoma, Ovarian Epithelial pathology
Carcinoma, Ovarian Epithelial mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1525-1438
- Volume :
- 34
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
- Publication Type :
- Academic Journal
- Accession number :
- 37945055
- Full Text :
- https://doi.org/10.1136/ijgc-2023-004736