Tandem phospha -Michael addition/cyclization/dehydration of 2-hydroxychalcones with H -phosphine oxides for the synthesis of 4-phosphorylated 4 H -chromenes.

Authors :: Wen Z
Yang KC
Zheng SL
Zhang YS
Wang SJ
Ni HL
Chen L
Source :: Organic & biomolecular chemistry [Org Biomol Chem] 2023 Nov 22; Vol. 21 (45), pp. 9076-9081. Date of Electronic Publication: 2023 Nov 22.
Publication Year :: 2023
Abstract: A Hg(OTf) <subscript>2</subscript> -catalyzed tandem phospha -Michael addition/cyclization/dehydration of 2-hydroxychalcones with H -phosphine oxides is presented. This protocol provides a new and supplementary approach for the preparation of 4-phosphorylated 4 H -chromenes in good yields (up to 99%). In addition, this domino reaction allows the successful construction of two new C-P and C-O bonds in a one-pot operation.

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