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Astrocytic transcriptional and epigenetic mechanisms of drug addiction.
- Source :
-
Journal of neural transmission (Vienna, Austria : 1996) [J Neural Transm (Vienna)] 2024 May; Vol. 131 (5), pp. 409-424. Date of Electronic Publication: 2023 Nov 08. - Publication Year :
- 2024
-
Abstract
- Addiction is a leading cause of disease burden worldwide and remains a challenge in current neuroscience research. Drug-induced lasting changes in gene expression are mediated by transcriptional and epigenetic regulation in the brain and are thought to underlie behavioral adaptations. Emerging evidence implicates astrocytes in regulating drug-seeking behaviors and demonstrates robust transcriptional response to several substances of abuse. This review focuses on the astrocytic transcriptional and epigenetic mechanisms of drug action.<br /> (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.)
Details
- Language :
- English
- ISSN :
- 1435-1463
- Volume :
- 131
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of neural transmission (Vienna, Austria : 1996)
- Publication Type :
- Academic Journal
- Accession number :
- 37940687
- Full Text :
- https://doi.org/10.1007/s00702-023-02716-4