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Direct arene trifluoromethylation enabled by promiscuous activity of fungal laccase.
- Source :
-
Organic & biomolecular chemistry [Org Biomol Chem] 2023 Nov 22; Vol. 21 (45), pp. 8975-8978. Date of Electronic Publication: 2023 Nov 22. - Publication Year :
- 2023
-
Abstract
- Laccase from Trametes versicolor was found to oxidize non-phenolic arenes and enable the trifluoromethylation of arenes in the presence of in situ generated CF <subscript>3</subscript> radicals at a catalyst loading as low as 0.0034%. The biocatalytic trifluoromethylation proceeded under mild conditions and could increase the yield by up to 12 fold, compared to the control.
- Subjects :
- Catalysis
Biocatalysis
Laccase metabolism
Trametes metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1477-0539
- Volume :
- 21
- Issue :
- 45
- Database :
- MEDLINE
- Journal :
- Organic & biomolecular chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 37933470
- Full Text :
- https://doi.org/10.1039/d3ob01779f