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ent -Clavilactone J and Its Quinone Derivative, Meroterpenoids from the Fungus Resupinatus sp.
- Source :
-
Journal of natural products [J Nat Prod] 2023 Nov 24; Vol. 86 (11), pp. 2580-2584. Date of Electronic Publication: 2023 Nov 06. - Publication Year :
- 2023
-
Abstract
- Metabolites 1 and 2 , isolated from cultures of the basidiomycete Resupinatus sp. BCC84615, collected in a tropical forest in northeastern Thailand, showed weak antibiotic activity against Bacillus subtilis and Staphylococcus aureus and cytotoxicity against cancer cell lines. Their planar structures were elucidated by high-resolution electrospray ionization mass spectrometry and NMR spectroscopy as clavilactone J, known from the basidiomycete Ampulloclitocybe clavipes , and its new 1,4-benzoquinone derivative. A detailed analysis of the ROESY correlations in 1 confirmed the recent revision of the relative configuration of clavilactone J. However, specific rotation and Cotton effects observed by electronic circular dichroism were contrary to those of the clavilactones; thus, we assigned a rare antipodal absolute configuration.
Details
- Language :
- English
- ISSN :
- 1520-6025
- Volume :
- 86
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 37931226
- Full Text :
- https://doi.org/10.1021/acs.jnatprod.3c00174