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The influence of dopamine autoreceptors on temperament and addiction risk.

Authors :: Zald DH
Source :: Neuroscience and biobehavioral reviews [Neurosci Biobehav Rev] 2023 Dec; Vol. 155, pp. 105456. Date of Electronic Publication: 2023 Nov 03.
Publication Year :: 2023
Abstract: As a major regulator of dopamine (DA), DA autoreceptors (DA <subscript>ARs</subscript> ) exert substantial influence over DA-mediated behaviors. This paper reviews the physiological and behavioral impact of DA <subscript>ARs</subscript> . Individual differences in DA <subscript>AR</subscript> functioning influences temperamental traits such as novelty responsivity and impulsivity, both of which are associated with vulnerability to addictive behavior in animal models and a broad array of externalizing behaviors in humans. DA <subscript>ARs</subscript> additionally impact the response to psychostimulants and other drugs of abuse. Human PET studies of D2-like receptors in the midbrain provide evidence for parallels to the animal literature. These data lead to the proposal that weak DA <subscript>AR</subscript> regulation is a risk factor for addiction and externalizing problems. The review highlights the potential to build translational models of the functional role of DA <subscript>ARs</subscript> in behavior. It also draws attention to key limitations in the current literature that would need to be addressed to further advance a weak DA <subscript>AR</subscript> regulation model of addiction and externalizing risk.<br />Competing Interests: Declarations of interest None<br /> (Copyright © 2023 Elsevier Ltd. All rights reserved.)