Back to Search
Start Over
Approach to the Epidemiology, Disease Management, and Current Challenges in the Management of Generalized Pustular Psoriasis Through a Survey Conducted Among Spanish Dermatologists.
- Source :
-
Actas dermo-sifiliograficas [Actas Dermosifiliogr] 2024 May; Vol. 115 (5), pp. 449-457. Date of Electronic Publication: 2023 Nov 02. - Publication Year :
- 2024
-
Abstract
- Background: Generalized pustular psoriasis (GPP) is a rare and severe inflammatory skin disease characterised by recurrent or intermittent flares. Epidemiological and disease management data in Spain are limited. Our goal was to estimate the epidemiology of GPP, explore its management, and reach consensus on the current challenges faced in Spain.<br />Methods: An electronic survey was submitted to dermatologists from the Spanish Academy of Dermatology and Venereology Psoriasis Working Group. This group is experienced in the management of GPP. It included a Delphi consensus to establish the current challenges.<br />Results: A total of 33 dermatologists responded to the survey. A 5-year prevalence and incidence of 13.05 and 7.01 cases per million inhabitants, respectively, were estimated. According to respondents, the most common GPP symptoms are pustules, erythema, and desquamation, while 45% of patients present > 1 annual flares. A total of 45% of respondents indicated that flares often require a length of stay between 1 and 2 weeks. In the presence of a flare, 67% of respondents often or always prescribe a non-biological systemic treatment as the first-line therapy [cyclosporine (55%); oral retinoid (30%)], and 45% a biological treatment [anti-TNFα (52%); anti-IL-17 (39%)]. The dermatologists agreed that the main challenges are to define and establish specific therapeutic goals to treat the disease including the patients' perspective on the management of the disease.<br />Conclusion: Our study describes the current situation on the management of GPP in Spain, increasing the present knowledge on the disease, and highlighting the current challenges faced at the moment.<br /> (Copyright © 2023. Publicado por Elsevier España, S.L.U.)
- Subjects :
- Humans
Spain epidemiology
Prevalence
Health Care Surveys
Practice Patterns, Physicians' statistics & numerical data
Dermatology statistics & numerical data
Incidence
Dermatologists statistics & numerical data
Disease Management
Delphi Technique
Male
Cyclosporine therapeutic use
Female
Retinoids therapeutic use
Psoriasis therapy
Psoriasis drug therapy
Psoriasis epidemiology
Subjects
Details
- Language :
- English; Spanish; Castilian
- ISSN :
- 1578-2190
- Volume :
- 115
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Actas dermo-sifiliograficas
- Publication Type :
- Academic Journal
- Accession number :
- 37925068
- Full Text :
- https://doi.org/10.1016/j.ad.2023.10.022