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Miniaturized paper-based analytical device for the portable analysis of phyto-cannabinoids in plant and oral fluids.
- Source :
-
Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2024 Jan; Vol. 416 (1), pp. 255-264. Date of Electronic Publication: 2023 Nov 04. - Publication Year :
- 2024
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Abstract
- In this work, a low-cost and eco-friendly paper-based analytical device (PAD) method is described for the determination of phyto-cannabinoids in cannabis and oral fluids based on a simple colorimetric reaction. The PAD was able to distinguish tetrahydrocannabinol (THC)- and cannabidiol (CBD)-rich plant samples by using 4-aminophenol (4-AP) and later on to quantify total phyto-cannabinoid content (THC + CBD + CBN) in plant and oral fluids by using the Fast Corinth V reagent. The chemical and physical properties regarding paper type and reagent concentration in the PAD were optimized to achieve the best analytical performance. After that, analytical features were obtained, including a linear range of 0.01-0.1 mg mL <superscript>-1</superscript> , a limit of detection (LOD) of 0.003 mg mL <superscript>-1</superscript> , and a suitable precision, expressed as relative standard deviation (RSD) lower than 10%. Furthermore, no significant interferences were observed in colorimetric reactions when tea, herbs, and drug samples were analyzed. Additionally, the PAD proved color stability up to 1 month after the sampling at 25 °C. The developed PAD was suitable for determining total phyto-cannabinoid content in plants and oral fluids, obtaining good results compared to GC-MS. Overall, this method showed good reliability resulting in an operational on-site device for drug monitoring.<br /> (© 2023. The Author(s).)
Details
- Language :
- English
- ISSN :
- 1618-2650
- Volume :
- 416
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Analytical and bioanalytical chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 37924377
- Full Text :
- https://doi.org/10.1007/s00216-023-05013-x