Back to Search
Start Over
Felodipine as a replacement for minoxidil in the treatment of severe hypertension.
- Source :
-
European heart journal [Eur Heart J] 1986 Oct; Vol. 7 (10), pp. 893-7. - Publication Year :
- 1986
-
Abstract
- The new calcium antagonist felodipine has been compared with minoxidil in the management of severe hypertension in a group of 17 men. Satisfactory control of blood pressure was achieved in all patients with a combination of beta blocker, loop diuretic and minoxidil after inadequate control on a standard regimen of beta blocker, thiazide and vasodilator. The optimal dose of felodipine was titrated after a placebo phase. In a double blind crossover trial blood pressure on felodipine (150/88 +/- 19/8 mmHg, SD) was the same as on minoxidil (148/87 +/- 23/11 mmHg, NS) and the postural difference was similar (NS) on both drug regimens. Body weight was lower on the felodipine regimen (P less than 0.01), as was supine heart rate (P less than 0.05). There was a small rise in plasma liver enzymes on felodipine therapy (P less than 0.01). Felodipine was well tolerated and may be useful in the management of severe hypertension.
- Subjects :
- Aged
Calcium Channel Blockers pharmacology
Felodipine
Heart Rate drug effects
Humans
Male
Middle Aged
Minoxidil pharmacology
Nitrendipine pharmacology
Nitrendipine therapeutic use
Random Allocation
Calcium Channel Blockers therapeutic use
Hypertension, Malignant drug therapy
Minoxidil therapeutic use
Nitrendipine analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 0195-668X
- Volume :
- 7
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- European heart journal
- Publication Type :
- Academic Journal
- Accession number :
- 3792351
- Full Text :
- https://doi.org/10.1093/oxfordjournals.eurheartj.a061977