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Expression of SmATPDases 1 and 2 in Schistosoma mansoni eggs favours IL-10 production in infected individuals.

Authors :
Gomides TAR
de Souza MLM
de Figueiredo AB
Lima MR
Silveira AMS
de Assis GFM
Fraga LAO
Silveira-Nunes G
Martucci L
Garcia JD
Afonso LCC
Teixeira-Carvalho A
Leite PM
Source :
Parasite immunology [Parasite Immunol] 2024 Jan; Vol. 46 (1), pp. e13017. Date of Electronic Publication: 2023 Nov 03.
Publication Year :
2024

Abstract

A role of IL-10 is down-regulating T-cell responses to schistosome antigens. Since SmATPDases can be correlated to modulation of the immune response, we evaluated the expression of enzymes in S. mansoni eggs. Faecal samples were collected from 40 infected individuals to detect coding regions of the SmATPDases. The cytokines were measured in supernatants of PBMC. The analysis was performed by the global median determination and set up high producers (HP) of cytokines. Six individuals expressed SmATPDase1, six expressed SmATPDase2 and six expressed both enzymes. The group who expressed only SmATPDase1 showed a high frequency of IFN-γ, TNF IL-4 HP; individuals who expressed only SmATPDase2 showed a high frequency of IFN-γ, IL-6 and IL-4 HP; and individuals who expressed both enzymes showed a high frequency of IL-10 HP. The comparison of the IFN-γ/IL-10 ratio presented higher indices in the group who had SmATPDase 2 expression than those who had the expression of both enzymes. The positive correlation between infection intensity and IL-10 levels remained only in the positive SmATPDase group. The IL-10 is the only cytokine induced by the expression of both enzymes. Our data suggest that the expression of both enzymes seems to be a factor that modulates the host immune response by inducing high IL-10 production.<br /> (© 2023 John Wiley & Sons Ltd.)

Details

Language :
English
ISSN :
1365-3024
Volume :
46
Issue :
1
Database :
MEDLINE
Journal :
Parasite immunology
Publication Type :
Academic Journal
Accession number :
37922505
Full Text :
https://doi.org/10.1111/pim.13017