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Fullerene C 60 protects against 7,12-dimethylbenz [a] anthracene (DMBA) induced-pancreatic damage via NF-κB and Nrf-2/HO-1 axis in rats.

Authors :
Beyaz S
Aslan A
Gok O
Ozercan IH
Agca CA
Source :
Toxicology research [Toxicol Res (Camb)] 2023 Sep 26; Vol. 12 (5), pp. 954-963. Date of Electronic Publication: 2023 Sep 26 (Print Publication: 2023).
Publication Year :
2023

Abstract

The objective of this investigation was to investigate the protective effects of fullerene C <subscript>60</subscript> nanoparticle against pancreatic damage experimentally induced by 7,12-dimethylbenz [a] anthracene (DMBA) in female rats. Fullerene C <subscript>60</subscript> nanoparticle was administered to rats 5 times a week by oral gavage (o.g) at 1.7 mg/kg bw 7 days after DMBA administration. 60 Wistar albino female rats divided to four groups; Groups: (1) Control group: Fed with standard diet; (2) Fullerene C <subscript>60</subscript> group: Fullerene C <subscript>60</subscript> (1.7 mg/kg bw); (3) DMBA group: DMBA (45 mg/kg bw); (4) Fullerene C <subscript>60</subscript>  + DMBA group: Fullerene C <subscript>60</subscript> (1.7 mg/kg bw) and DMBA (45 mg/kg bw). Lipid peroxidation malondialdehyde (MDA), catalase activity (CAT) and glutathione (GSH) levels in pancreatic tissue were determined by spectrophotometer. Protein expression levels of p53, HO-1, p38-α (MAPK), Nrf-2, NF-κB and COX-2 in pancreatic tissue were determined by western blotting technique. In our findings, compared to the group given DMBA, MDA levels and p38-α, NF-κB and COX-2 levels decreased, CAT activity, GSH level, total protein density and p53, HO-1, Nrf-2 levels in the groups given fullerene C <subscript>60</subscript> nanoparticle an increase in expression levels was observed. Our results showed that fullerene C <subscript>60</subscript> nanoparticle may be more beneficial in preventing pancreatic damage.<br />Competing Interests: No potential conflict of interest was reported by the author(s). All authors have read and approved the final article.<br /> (© The Author(s) 2023. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)

Details

Language :
English
ISSN :
2045-452X
Volume :
12
Issue :
5
Database :
MEDLINE
Journal :
Toxicology research
Publication Type :
Academic Journal
Accession number :
37915491
Full Text :
https://doi.org/10.1093/toxres/tfad092