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Effect of macrophage polarization on parasitic protection against type 1 diabetes mellitus.
- Source :
-
Experimental parasitology [Exp Parasitol] 2024 Jan; Vol. 256, pp. 108649. Date of Electronic Publication: 2023 Oct 31. - Publication Year :
- 2024
-
Abstract
- Type 1 diabetes mellitus is a chronic disease caused by the destruction of pancreatic beta cells. Based on the hygiene hypothesis, a growing body of evidence suggests a negative association between parasitic infections and diabetes in humans and animal models. The mechanism of parasite-mediated prevention of type 1 diabetes mellitus may be related to the adaptive and innate immune systems. Macrophage polarization is a new paradigm for the treatment of type 1 diabetes mellitus, and different host macrophage subsets play various roles during parasite infection. Proinflammatory cytokines are released by M1 macrophages, which are important in the development of type 1 diabetes mellitus. Parasite-activated M2 macrophages prevent the development of type 1 diabetes mellitus and can influence the development of adaptive immune responses through several mechanisms, including Th2 cells and regulatory T cells. Here, we review the role and mechanism of macrophage polarization in parasitic protection against type 1 diabetes mellitus.<br />Competing Interests: Declaration of competing interest No.<br /> (Copyright © 2023. Published by Elsevier Inc.)
Details
- Language :
- English
- ISSN :
- 1090-2449
- Volume :
- 256
- Database :
- MEDLINE
- Journal :
- Experimental parasitology
- Publication Type :
- Academic Journal
- Accession number :
- 37914152
- Full Text :
- https://doi.org/10.1016/j.exppara.2023.108649