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The potential role of ferroptosis in the physiopathology of deep tissue injuries.
- Source :
-
International wound journal [Int Wound J] 2023 Oct 31. Date of Electronic Publication: 2023 Oct 31. - Publication Year :
- 2023
- Publisher :
- Ahead of Print
-
Abstract
- Deep tissue injuries (DTIs) are a serious type of pressure injuries that mainly occur at the bony prominences and can develop rapidly, making prevention and treatment more difficult. Although consistent research efforts have been made over the years, the cellular and molecular mechanisms contributing to the development of DTIs remain unclear. More recently, ferroptosis, a novel regulatory cell death (RCD) type, has been identified that is morphological, biochemical and genetic criteria distinct from apoptosis, autophagy and other known cell death pathways. Ferroptosis is characterized by iron overload, iron-dependent lipid peroxidation and shrunken mitochondria. We also note that some of the pathological features of DTI are known to be key features of the ferroptosis pathway. Numerous studies have confirmed that ferroptosis may be involved in chronic wounds, including DTIs. Here, we elaborate on the basic pathological features of ferroptosis. We also present the evidence that ferroptosis is involved in the pathology of DTIs and highlight a future perspective on this emerging field, desiring to provide more possibilities for the prevention and treatment of DTIs.<br /> (© 2023 The Authors. International Wound Journal published by Medicalhelplines.com Inc and John Wiley & Sons Ltd.)
Details
- Language :
- English
- ISSN :
- 1742-481X
- Database :
- MEDLINE
- Journal :
- International wound journal
- Publication Type :
- Academic Journal
- Accession number :
- 37905685
- Full Text :
- https://doi.org/10.1111/iwj.14466