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A primary pediatric acute myelomonocytic leukemia with t(3;21)(q26;q22): A case report.

Authors :
Duan JX
Liu F
Chang L
Che GL
Yang QX
Teng J
Jian H
Liu XJ
Lai SY
Source :
Medicine [Medicine (Baltimore)] 2023 Oct 27; Vol. 102 (43), pp. e35721.
Publication Year :
2023

Abstract

Rationale: The rare t(3;21)(q26;q22) translocation results in gene fusion and generates multiple fusion transcripts, which are typically associated with therapy-related myelodysplastic syndrome, acute myeloid leukemia, and chronic myelogenous leukemia. Here, we report a rare case of de novo acute myelomonocytic leukemia in a young child with t(3;21)(q26;q22).<br />Patient Concerns: A 2-and-a-half-year-old female patient presented with abdominal pain, cough, paleness, and fever for 3 weeks, without any history of malignant diseases.<br />Diagnoses: Chest computed tomography revealed pneumonia. Bone marrow smear confirmed acute myelomonocytic leukemia. Cytogenetic analysis and Sanger sequencing identified RUNX1-MECOM and RUNX1-RPL22 fusion genes as a result of t(3;21)(q26;q22).<br />Interventions: The patient received 3 courses of chemotherapy, but bone marrow smear examination showed no remission. According to the wishes of the patient family, the allogeneic hematopoietic stem cell transplantation (Allo-HSCT) was chosen.<br />Outcomes: The patient did not experience any adverse reactions after Allo-HSCT. The red blood cells and platelets increased without transfusion. The pneumonia recovered after antibiotic treatment.<br />Lessons: The patient recovered well after Allo-HSCT. Therefore, for patients with RUNX1-MECOM and RUNX1-RPL22 fusion genes, transplantation may be a good choice when chemotherapy is not effective.<br />Competing Interests: The authors have no conflicts of interest to disclose.<br /> (Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.)

Details

Language :
English
ISSN :
1536-5964
Volume :
102
Issue :
43
Database :
MEDLINE
Journal :
Medicine
Publication Type :
Academic Journal
Accession number :
37904382
Full Text :
https://doi.org/10.1097/MD.0000000000035721