Development of 225 Ac Production from Low Isotopic Dilution 229 Th.

Authors :: Camacaro JF
Dunckley CP
Harman SE
Fitzgerald HA
Lakes AL
Liao Z
Ludwig RC
McBride KM
Yalcintas Bethune E
Younes A
Chatterjee S
Lilley LM
Source :: ACS omega [ACS Omega] 2023 Sep 27; Vol. 8 (42), pp. 38822-38827. Date of Electronic Publication: 2023 Sep 27 (Print Publication: 2023).
Publication Year :: 2023
Abstract: The promise of <superscript>225</superscript> Ac targeted alpha therapies has been on the horizon for the last two decades. TerraPower Isotopes are uniquely suited to produce clinically relevant quantities of <superscript>225</superscript> Ac through the decay of <superscript>229</superscript> Th. Herein, a rapid processing scheme to isolate radionuclidic and radioisotopically pure <superscript>225</superscript> Ac in good yield (98%) produced from <superscript>229</superscript> Th that contains significant quantities of <superscript>228</superscript> Th activity is described. The characterization of each step of the process is presented along with the detailed characterization of the resulting <superscript>225</superscript> Ac isotopic starting material that will support the cancer research and development efforts.<br />Competing Interests: The authors declare no competing financial interest.<br /> (© 2023 The Authors. Published by American Chemical Society.)