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Does statin suppress oxaliplatin-induced peripheral neuropathy in patients with colorectal cancer? A single-center observational study.
- Source :
-
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2023 Oct 28; Vol. 31 (12), pp. 660. Date of Electronic Publication: 2023 Oct 28. - Publication Year :
- 2023
-
Abstract
- Background: Oxaliplatin-induced peripheral neuropathy (OIPN) is a common and dose-limiting toxicity that markedly limits the use of oxaliplatin and affects quality of life. Statins have been shown to exert neuroprotective effects in preclinical settings. The aim of the present study was to clarify whether statins prevented OIPN in patients with colorectal cancer (CRC) receiving adjuvant CAPOX therapy.<br />Methods: We examined 224 patients who received adjuvant CAPOX therapy for CRC between July 2010 and December 2021 at our hospital. Patients were divided into "Statin" and "Non-statin" groups based on statin use. Details on and the adverse events of adjuvant CAPOX therapy were examined in association with statin use.<br />Results: Thirty-one patients (14%) were treated with statins. There were no intergroup differences in the relative dose intensity or number of CAPOX cycles between the Statin and Non-statin groups. In total, 94% of patients in the Statin group and 95% of those in the Non-statin group developed OIPN (p=0.67). The severity of OIPN was similar between the two groups (p=0.89). The frequency of treatment delays in CAPOX did not significantly differ between the Statin and Non-statin groups (16% vs. 11%, p=0.45).<br />Conclusions: The efficacy of statins to attenuate OIPN during adjuvant CAPOX therapy was not apparent in the current study. Further studies are needed to confirm the present results.<br /> (© 2023. The Author(s).)
- Subjects :
- Humans
Oxaliplatin
Fluorouracil adverse effects
Quality of Life
Antineoplastic Combined Chemotherapy Protocols adverse effects
Organoplatinum Compounds
Chemotherapy, Adjuvant adverse effects
Capecitabine
Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use
Peripheral Nervous System Diseases chemically induced
Peripheral Nervous System Diseases drug therapy
Peripheral Nervous System Diseases prevention & control
Colorectal Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1433-7339
- Volume :
- 31
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 37897532
- Full Text :
- https://doi.org/10.1007/s00520-023-08134-2