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2D Nanozymes Modulate Gut Microbiota and T-Cell Differentiation for Inflammatory Bowel Disease Management.
- Source :
-
Advanced healthcare materials [Adv Healthc Mater] 2024 Feb; Vol. 13 (4), pp. e2302576. Date of Electronic Publication: 2023 Nov 15. - Publication Year :
- 2024
-
Abstract
- Intestinal commensal microbiota dysbiosis and immune dysfunction are significant exacerbating factors in inflammatory bowel disease (IBD). To address these problems, Pluronic F-127-coated tungsten diselenide (WSe <subscript>2</subscript> @F127) nanozymes are developed by simple liquid-phase exfoliation. The abundant valence transitions of elemental selenium (Se <superscript>2-</superscript> /Se <superscript>4+</superscript> ) and tungsten (W <superscript>4+</superscript> /W <superscript>6+</superscript> ) enable the obtained WSe <subscript>2</subscript> @F127 nanozymes to eliminate reactive oxygen/nitrogen species. In addition, the released tungsten ions are capable of inhibiting the proliferation of Escherichia coli. In a model of dextran sodium sulfate-induced colitis, WSe <subscript>2</subscript> @F127 nanozymes modulate the gut microbiota by increasing the abundance of bacteria S24-7 and significantly reducing the abundance of Enterobacteriaceae. Moreover, WSe <subscript>2</subscript> @F127 nanozymes inhibit T-cell differentiation and improve intestinal immune barrier function in a model of Crohn's disease. The WSe <subscript>2</subscript> @F127 nanozymes effectively alleviate IBD by reducing oxidative stress damage, modulating intestinal microbial populations, and remodeling the immune barrier.<br /> (© 2023 Wiley-VCH GmbH.)
Details
- Language :
- English
- ISSN :
- 2192-2659
- Volume :
- 13
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Advanced healthcare materials
- Publication Type :
- Academic Journal
- Accession number :
- 37897434
- Full Text :
- https://doi.org/10.1002/adhm.202302576