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Proteomes reveal metabolic capabilities of Yarrowia lipolytica for biological upcycling of polyethylene into high-value chemicals.
- Source :
-
MSystems [mSystems] 2023 Dec 21; Vol. 8 (6), pp. e0074123. Date of Electronic Publication: 2023 Oct 26. - Publication Year :
- 2023
-
Abstract
- Importance: Sustainable processes for biological upcycling of plastic wastes in a circular bioeconomy are needed to promote decarbonization and reduce environmental pollution due to increased plastic consumption, incineration, and landfill storage. Strain characterization and proteomic analysis revealed the robust metabolic capabilities of Yarrowia lipolytica to upcycle polyethylene into high-value chemicals. Significant proteome reallocation toward energy and lipid metabolisms was required for robust growth on hydrocarbons with n-hexadecane as the preferential substrate. However, an apparent over-investment in these same categories to utilize complex depolymerized plastic (DP) oil came at the expense of protein biosynthesis, limiting cell growth. Taken together, this study elucidates how Y. lipolytica activates its metabolism to utilize DP oil and establishes Y. lipolytica as a promising host for the upcycling of plastic wastes.<br />Competing Interests: The authors declare no conflict of interest.
- Subjects :
- Proteome metabolism
Polyethylene metabolism
Proteomics
Lipid Metabolism
Yarrowia
Subjects
Details
- Language :
- English
- ISSN :
- 2379-5077
- Volume :
- 8
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- MSystems
- Publication Type :
- Academic Journal
- Accession number :
- 37882587
- Full Text :
- https://doi.org/10.1128/msystems.00741-23