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Co-administration of chicken IL-2 alleviates clinical signs and replication of the ILTV chicken embryo origin vaccine by pre-activating natural killer cells and cytotoxic T lymphocytes.
- Source :
-
Journal of virology [J Virol] 2023 Nov 30; Vol. 97 (11), pp. e0132223. Date of Electronic Publication: 2023 Oct 26. - Publication Year :
- 2023
-
Abstract
- Importance: Chickens immunized with the infectious laryngotracheitis chicken embryo origin (CEO) vaccine (Medivac, PT Medion Farma Jaya) experience adverse reactions, hindering its safety and effective use in poultry flocks. To improve the effect of the vaccine, we sought to find a strategy to alleviate the respiratory reactions associated with the vaccine. Here, we confirmed that co-administering the CEO vaccine with chIL-2 by oral delivery led to significant alleviation of the vaccine reactions in chickens after immunization. Furthermore, we found that the co-administration of chIL-2 with the CEO vaccine reduced the clinical signs of the CEO vaccine while enhancing natural killer cells and cytotoxic T lymphocyte response to decrease viral loads in their tissues, particularly in the trachea and conjunctiva. Importantly, we demonstrated that the chIL-2 treatment can ameliorate the replication of the CEO vaccine without compromising its effectiveness. This study provides new insights into further applications of chIL-2 and a promising strategy for alleviating the adverse reaction of vaccines.<br />Competing Interests: The authors declare no conflict of interest.
- Subjects :
- Animals
Administration, Oral
Conjunctiva virology
Poultry Diseases immunology
Poultry Diseases prevention & control
Poultry Diseases virology
Respiratory Tract Diseases immunology
Respiratory Tract Diseases prevention & control
Respiratory Tract Diseases veterinary
Respiratory Tract Diseases virology
Trachea virology
Viral Load
Chickens immunology
Chickens virology
Herpesviridae Infections immunology
Herpesviridae Infections prevention & control
Herpesviridae Infections veterinary
Herpesviridae Infections virology
Herpesvirus 1, Gallid immunology
Interleukin-2 administration & dosage
Interleukin-2 immunology
Killer Cells, Natural immunology
T-Lymphocytes, Cytotoxic immunology
Viral Vaccines administration & dosage
Viral Vaccines adverse effects
Viral Vaccines biosynthesis
Viral Vaccines immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1098-5514
- Volume :
- 97
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of virology
- Publication Type :
- Academic Journal
- Accession number :
- 37882519
- Full Text :
- https://doi.org/10.1128/jvi.01322-23