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A case report on Mycobacterium houstonense infection after total hip arthroplasty.
- Source :
-
BMC infectious diseases [BMC Infect Dis] 2023 Oct 25; Vol. 23 (1), pp. 722. Date of Electronic Publication: 2023 Oct 25. - Publication Year :
- 2023
-
Abstract
- Background: Mycobacterium houstonense is a category of rapidly growing mycobacteria that is gram-positive, acid-fast, polycrystalline, and non-spore-forming. There have been few reports of human infection caused by Mycobacterium houstonense worldwide.<br />Case Presentation: We present a case of chronic periprosthetic joint infection caused by Mycobacterium houstonense in an elderly female patient. The patient developed signs of infection after undergoing total hip arthroplasty. Despite receiving antibiotic treatment and revision surgery, the signs of infection recurred repeatedly. Multiple bacterial cultures during the treatment period were negative. Later, we identified the pathogenic bacteria Mycobacterium houstonense through mNGS testing, isolated the bacteria from the ultrasonically centrifuged fluid of the prosthesis and obtained drug sensitivity results. Finally, we performed a revision surgery and treated the patient with moxifloxacin and clindamycin. After treatment, the patient did not show signs of infection recurrence during 24 months of follow-up.<br />Conclusion: Through a relevant literature search, we believe that Mycobacterium houstonense may show higher sensitivity to amikacin and quinolone antibiotics. Additionally, clarifying occult infection sources through methods such as gene testing will improve the diagnosis and treatment of periprosthetic joint infection.<br /> (© 2023. BioMed Central Ltd., part of Springer Nature.)
- Subjects :
- Aged
Female
Humans
Anti-Bacterial Agents therapeutic use
Reoperation
Arthroplasty, Replacement, Hip adverse effects
Mycobacteriaceae
Mycobacterium Infections diagnosis
Mycobacterium Infections drug therapy
Mycobacterium Infections complications
Prosthesis-Related Infections diagnosis
Prosthesis-Related Infections drug therapy
Prosthesis-Related Infections etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2334
- Volume :
- 23
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 37880617
- Full Text :
- https://doi.org/10.1186/s12879-023-08705-y