CTNNB1 somatic mutations drive Wnt pathway activation in a case of incidental intranodal palisaded myofibroblastoma.

Authors :: Moreno de Juan G
Montes Moreno S
Source :: Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de Citologia [Rev Esp Patol] 2023 Oct-Dec; Vol. 56 (4), pp. 279-283. Date of Electronic Publication: 2023 May 01.
Publication Year :: 2023
Abstract: Intranodal palisaded myofibroblastoma (IPM) is a rare stroma-derived spindle-cell neoplasm of the lymph node with myofibroblastic differentiation and CTNNB1 (β-catenin gene) somatic mutations. We present a case of IPM found incidentally in the staging of lung adenocarcinoma. We describe the major histopathological and phenotypic features, including a palisaded bland spindle cell proliferation with myofibroblastic differentiation and Wnt pathway activation by immunohistochemistry, including β-catenin expression. Production of osteoid-like collagen directly from tumor cells was observed. We confirmed p.Gly34Arg CTNNB1 mutation by direct sequencing. We also reviewed the literature for similar cases.<br /> (Copyright © 2023 Sociedad Española de Anatomía Patológica. Publicado por Elsevier España, S.L.U. All rights reserved.)

Subjects :: Humans
Wnt Signaling Pathway genetics
Lymph Nodes pathology
Mutation
beta Catenin genetics
beta Catenin metabolism
Neoplasms, Muscle Tissue genetics
Neoplasms, Muscle Tissue metabolism
Neoplasms, Muscle Tissue pathology

Language :: English
ISSN :: 1988-561X
Volume :: 56
Issue :: 4
Database :: MEDLINE
Journal :: Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de Citologia
Publication Type :: Report
Accession number :: 37879826
Full Text :: https://doi.org/10.1016/j.patol.2023.02.003

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