Encephalic meningioangiomatosis in a dog with high-grade undefined glioma.

Authors :: Silveira BO
de Melo SMP
Cony FG
Serena GC
Pereira VC
de Castro LT
Wodzik VS
Bandinelli MB
Panziera W
Pavarini SP
Source :: Journal of comparative pathology [J Comp Pathol] 2023 Nov; Vol. 207, pp. 1-5. Date of Electronic Publication: 2023 Oct 20.
Publication Year :: 2023
Abstract: Meningioangiomatosis (MA) is a rare proliferative meningovascular disorder that affects mainly the cerebral cortex, brainstem and spinal cord of humans and animals and can coexist with other proliferative disorders. A 7.5-year-old male Brazilian Campeiro Bulldog died after a convulsive crisis and cardiorespiratory arrest. At necropsy, a firm, white mass involving the piriform and right occipital lobes was seen. Histologically, the mass consisted of two morphologically distinct entities that collided: a congenital malformation characterized by a proliferation of meningothelial cells around blood vessels, within the perivascular spaces; and a neoplasm composed of two cell populations with astrocytic and oligodendrocytic differentiation. Meningothelial cells and neoplastic glial cells immunolabelled for vimentin. This first reported case of encephalic MA with a high-grade undefined glioma in a dog was confirmed through clinical signs, pathological and immunohistochemical findings.<br /> (Copyright © 2023 Elsevier Ltd. All rights reserved.)