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Synergistic investigation of natural and synthetic C1-trophic microorganisms to foster a circular carbon economy.
- Source :
-
Nature communications [Nat Commun] 2023 Oct 21; Vol. 14 (1), pp. 6673. Date of Electronic Publication: 2023 Oct 21. - Publication Year :
- 2023
-
Abstract
- A true circular carbon economy must upgrade waste greenhouse gases. C1-based biomanufacturing is an attractive solution, in which one carbon (C1) molecules (e.g. CO <subscript>2</subscript> , formate, methanol, etc.) are converted by microbial cell factories into value-added goods (i.e. food, feed, and chemicals). To render C1-based biomanufacturing cost-competitive, we must adapt microbial metabolism to perform chemical conversions at high rates and yields. To this end, the biotechnology community has undertaken two (seemingly opposing) paths: optimizing natural C1-trophic microorganisms versus engineering synthetic C1-assimilation de novo in model microorganisms. Here, we pose how these approaches can instead create synergies for strengthening the competitiveness of C1-based biomanufacturing as a whole.<br /> (© 2023. Springer Nature Limited.)
- Subjects :
- Methanol metabolism
Biotechnology
Carbon metabolism
Metabolic Engineering
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 37865689
- Full Text :
- https://doi.org/10.1038/s41467-023-42166-w