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Cortisol as a Target for Treating Mental Disorders: A Promising Avenue for Therapy.

Authors :
Patel VK
Vaishnaw A
Shirbhate E
Kore R
Singh V
Veerasamy R
Rajak H
Source :
Mini reviews in medicinal chemistry [Mini Rev Med Chem] 2024; Vol. 24 (6), pp. 588-600.
Publication Year :
2024

Abstract

Cortisol, commonly known as the "stress hormone," plays a critical role in the body's response to stress. Elevated cortisol levels have been associated with various mental disorders, including anxiety, depression, and post-traumatic stress disorder. Consequently, researchers have explored cortisol modulation as a promising avenue for treating these conditions. However, the availability of research on cortisol as a therapeutic option for mental disorders is limited, and existing studies employ diverse methodologies and outcome measures. This review article aimed to provide insights into different treatment approaches, both pharmacological and non-pharmacological, which can effectively modulate cortisol levels. Pharmacological interventions involve the use of substances, such as somatostatin analogs, dopamine agonists, corticotropin-releasing hormone antagonists, and cortisol synthesis inhibitors. Additionally, non-pharmacological techniques, including cognitivebehavioral therapy, herbs and supplements, transcranial magnetic stimulation, lifestyle changes, and surgery, have been investigated to reduce cortisol levels. The emerging evidence suggests that cortisol modulation could be a promising treatment option for mental disorders. However, more research is needed to fully understand the effectiveness and safety of these therapies.<br /> (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

Details

Language :
English
ISSN :
1875-5607
Volume :
24
Issue :
6
Database :
MEDLINE
Journal :
Mini reviews in medicinal chemistry
Publication Type :
Academic Journal
Accession number :
37861053
Full Text :
https://doi.org/10.2174/0113895575262104230928042150