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COVID-19 risk, course and outcome in people with mental disorders: a systematic review and meta-analyses.
- Source :
-
Epidemiology and psychiatric sciences [Epidemiol Psychiatr Sci] 2023 Oct 20; Vol. 32, pp. e61. Date of Electronic Publication: 2023 Oct 20. - Publication Year :
- 2023
-
Abstract
- Aims: It has been suggested that people with mental disorders have an elevated risk to acquire severe acute respiratory syndrome coronavirus 2 and to be disproportionally affected by coronavirus disease 19 (COVID-19) once infected. We aimed to analyse the COVID-19 infection rate, course and outcome, including mortality and long COVID, in people with anxiety, depressive, neurodevelopmental, schizophrenia spectrum and substance use disorders relative to control subjects without these disorders.<br />Methods: This study constitutes a preregistered systematic review and random-effects frequentist and Bayesian meta-analyses. Major databases were searched up until 27 June 2023.<br />Results: Eighty-one original articles were included reporting 304 cross-sectional and prospective effect size estimates (median n per effect-size = 114837) regarding associations of interest. Infection risk was not significantly increased for any mental disorder that we investigated relative to samples of people without these disorders. The course of COVID-19, however, is relatively severe, and long COVID and COVID-19-related hospitalization are more likely in all patient samples that we investigated. The odds of dying from COVID-19 were high in people with most types of mental disorders, except for those with anxiety and neurodevelopmental disorders relative to non-patient samples (pooled ORs range, 1.26-2.57). Bayesian analyses confirmed the findings from the frequentist approach and complemented them with estimates of the strength of evidence.<br />Conclusions: Once infected, people with pre-existing mental disorders are at an elevated risk for a severe COVID-19 course and outcome, including long COVID and mortality, relative to people without pre-existing mental disorders, despite an infection risk not significantly increased.
Details
- Language :
- English
- ISSN :
- 2045-7979
- Volume :
- 32
- Database :
- MEDLINE
- Journal :
- Epidemiology and psychiatric sciences
- Publication Type :
- Academic Journal
- Accession number :
- 37859501
- Full Text :
- https://doi.org/10.1017/S2045796023000719