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Changes of Locomotor Activity by Dopamine D2, D3 Agonist Quinpirole in Mice Using Home-cage Monitoring System.
- Source :
-
Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology [Clin Psychopharmacol Neurosci] 2023 Nov 30; Vol. 21 (4), pp. 686-692. Date of Electronic Publication: 2023 May 22. - Publication Year :
- 2023
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Abstract
- Objective: : As dopamine is closely linked to locomotor activities, animal studies on locomotor activities using dopaminergic agents were widely done. However, most of animal studies were performed for a short period that there is a lack of longitudinal study on the effects of dopaminergic agents on locomotor activities. This study aimed to examine the longterm effect of a dopamine D2, D3 agonist quinpirole on locomotor activities in mice using a home-cage monitoring system.<br />Methods: : The locomotor activities of Institute Cancer Research mice were measured by infrared motion detectors in home-cages under the 12-hour dark and 12-hour light condition for three days after the quinpirole injection. Quinpirole was injected at a concentration of 0.5 mg/kg intraperitoneally in the beginning of the dark phase. The locomotor activities before and after the quinpirole administration were compared by the Wilcoxon signed-rank test and one-way repeated measures ANOVA.<br />Results: : After the quinpirole administration, the 24-hour total locomotor activity did not change ( p = 0.169), but activities were significantly increased in the 12-hour dark phase sum ( p = 0.013) and decreased in the 12-hour light phase sum ( p = 0.009). Significant increases in the activities were observed in the dark-light difference ( p = 0.005) and dark-light ratio ( p = 0.005) as well.<br />Conclusion: : This study suggests that quinpirole injection entrains the circadian rest-activity rhythm of locomotor activities. Therefore, quinpirole can be a drug that mediates locomotor activity as a dopamine agonist as well as a modulator of the circadian rhythms.
Details
- Language :
- English
- ISSN :
- 1738-1088
- Volume :
- 21
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 37859441
- Full Text :
- https://doi.org/10.9758/cpn.22.1016