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[Megakaryocytopoiesis studied in a mathematical model. 2. Regulation of cell differentiation following damage to part of the proliferating bone marrow pool by hydroxyurea].
- Source :
-
Ontogenez [Ontogenez] 1986 Sep-Oct; Vol. 17 (5), pp. 541-4. - Publication Year :
- 1986
-
Abstract
- Analysis of the earlier obtained data on the effect of hydroxyurea on megakaryocytopoiesis by a simulation model has shown that differentiation of proliferating precursors of the megakaryocytes depends on their amount in bone marrow; the time of their involvement in the proliferating pool increases if the number of proliferating cells decreases. Within 24 h after the treatment with hydroxyurea (900 mg/kg), the transit time for the mouse megakaryocytes is reduced by about 14 h due to acceleration of the latest developmental stages. A hypothesis is put forward which accounts for correlation between the duration of proliferative period and the volume and maturation time of megakaryocytes.
Details
- Language :
- Russian
- ISSN :
- 0475-1450
- Volume :
- 17
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Ontogenez
- Publication Type :
- Academic Journal
- Accession number :
- 3785876