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Neuronal γ-secretase regulates synaptic functions via cholesterol homeostasis.
- Source :
-
Neuron [Neuron] 2023 Oct 18; Vol. 111 (20), pp. 3133-3135. - Publication Year :
- 2023
-
Abstract
- In this issue of Neuron, Essayan-Perez and Südhof <superscript>1</superscript> demonstrate roles for γ-secretase in the regulation of synaptic functions in human neurons. Chronic attenuation of γ-secretase activity increases synapse formation but decreases neurotransmission (i.e., the probability of presynaptic release), likely due to impairment of cholesterol metabolism.<br />Competing Interests: Declaration of interests The authors declare no competing interests.<br /> (Copyright © 2023 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1097-4199
- Volume :
- 111
- Issue :
- 20
- Database :
- MEDLINE
- Journal :
- Neuron
- Publication Type :
- Academic Journal
- Accession number :
- 37857086
- Full Text :
- https://doi.org/10.1016/j.neuron.2023.09.021