Workplace Productivity Loss and Indirect Costs Associated With Preterm Birth in the United States.

Objective: To estimate workplace productivity loss and indirect costs in the year after birth among individuals who deliver preterm in the United States.
Methods: This retrospective, observational cohort study estimated workplace productivity loss and indirect costs for individuals aged 18-55 years with an inpatient delivery between January 1, 2016, and September 30, 2021, using data from the Merative MarketScan Commercial Claims and Encounters database and the Health and Productivity Management database. Workdays lost and costs attributable to medical-related absenteeism, workplace absenteeism (defined as sick leave, leave, recreational leave, Family Medical Leave Act); disability (defined as short-term and long-term disability), and aggregate workplace productivity loss, a combined outcome measure, were compared between propensity-score-matched birth cohorts: preterm birth (before 37 weeks of gestation) and full-term birth (at or after 37 weeks of gestation). Outcomes were also compared between the full-term birth cohort and preterm birth subgroups (before 32 weeks of gestation and before 34 weeks of gestation). Estimations of indirect costs assumed an 8-hour workday. Costs were inflated to December 2021 U.S. dollars.
Results: In total, 37,522 individuals were eligible for medical-related absenteeism, 1,028 for workplace absenteeism, 7,880 for disability, and 396 for aggregate workplace productivity loss after propensity score matching. Compared with full-term birth, preterm birth was associated with more workdays lost and costs in the year after childbirth attributable to medical-related absenteeism (differences of 4.2 days and $1,045, P <.001) and disability (differences of 2.8 days and $422, P <.001). Preterm birth was not associated with workplace absenteeism (differences of 1.4 days and $347, P =.787) and aggregate workplace productivity loss (differences of 5.2 days [ P =.080] and $1,021 [ P =.093]). Numerical differences were greater in magnitude and inversely related to gestational age at birth across outcomes.
Conclusion: Preterm birth was associated with medical-related absenteeism, disability claims, and indirect costs in the year after birth compared with full-term birth.
Competing Interests: Financial Disclosure Vanessa Perez Patel, James Li, Seungyoung Hwang, and Damien Croft are employees of Organon. Organon provided consultancy fees to Matthew Davis and Scott Johnson (employees of Medicus Economics). Scott Johnson disclosed that money was paid to his institution from Acadia, Sunovion, and Vertex. He also disclosed having relationships with the following: Agios, Albireo, Alexion, Apellis, Argenx, Astellas, BCG, BeyondSpring, Boehringer-Ingelheim, Biohaven, BMS, Celgene, Decibel, Deciphera, Drexel, Esperion, FAST F2G, Fulcrum, Genentech, GRAIL, Include Health, IVI Kite, Madrigal, Morphosys, Novo Nordisk, Oncopeptides, Organon, Penn, Pfizer, PharmaEssentia, PTC, Rallybio, Reata, Regeneron, Sage, Sanofi, Sarepta, Snell, Spark, and SPR Therapeutics. Jane Kondejewski is an employee of Snell Medical Communication and disclosed the following: SNELL Medical Communication Inc. is a medical communications company that has provided medical writing and editorial services to the following clients: 3DS/Medidata Solutions, Analysis Group, BeiGene, BMS, Broadstreet, Eisai, Organon, Sage Therapeutics, Sarepta, Sunovion Pharmaceuticals, Takeda. Money was paid to her institution from 3DS/Medidata Solutions, Analysis Group, BeiGene, BMS, Broadstreet, Eisai, Organon, Sage Therapeutics, Sarepta, Sunovion Pharmaceuticals, and Takeda. Kara Rood is an employee of The Ohio State University. Hyagriv Simhan is an employee of the University of Pittsburgh and an advisor to Organon. The other authors did not report any potential conflicts of interest. The funding source conceptualized the study and contributed to the design, analysis, interpretation, and authoring of this study and reviewed the manuscript to ensure quality and protection of intellectual property; the authors were solely responsible for the final content of the manuscript and decision to submit for publication.
(Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.)