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Rates and correlates of medication non-adherence behaviors and attitudes in adult patients with early psychosis.
- Source :
-
Social psychiatry and psychiatric epidemiology [Soc Psychiatry Psychiatr Epidemiol] 2024 Jul; Vol. 59 (7), pp. 1215-1225. Date of Electronic Publication: 2023 Oct 14. - Publication Year :
- 2024
-
Abstract
- Purpose: Literature on antipsychotic medication adherence in early psychosis primarily assessed adherence behaviors and focused on young patients. There is a paucity of research investigating negative medication attitude and its determinants in the early illness course, particularly in older-aged sample. We aimed to examine prevalence and correlates of medication non-adherence behaviors and negative medication attitudes separately in adult patients with early psychosis.<br />Methods: One hundred ninety-nine Chinese early psychosis patients aged 26-55 years who had received three-year treatment for first psychotic episode in Hong Kong were examined. Assessments encompassing socio-demographics, premorbid adjustment, clinical and treatment profiles, self-stigma and therapeutic alliance were conducted. Patients were evaluated with Medication Compliance Questionnaire, which is a modified Chinese-translated version of Medication Adherence Rating Scale and includes items measuring adherence behaviors and attitudes towards medications.<br />Results: Rates of medication non-adherence and negative attitude towards medications were 38.7% and 50.8%, respectively. Multivariate regression analysis showed that more severe positive symptoms, greater self-stigma and negative medication attitude were independently associated with medication non-adherence. Negative attitude towards medications was significantly associated with younger age, higher educational attainment, diagnosis of other psychotic disorders, poorer insight, greater self-stigma and less satisfaction with communication with healthcare staff, which represented an index reflecting suboptimal therapeutic alliance.<br />Conclusion: Antipsychotic non-adherence and negative medication attitudes are frequently observed in adult early psychosis patients. Our findings indicate that poor insight, elevated self-stigma and suboptimal therapeutic alliance may constitute potential treatment targets for promoting medication adherence and rectifying negative medication attitudes in the early illness stage.<br /> (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.)
- Subjects :
- Humans
Adult
Male
Female
Middle Aged
Hong Kong
Surveys and Questionnaires
Social Stigma
Psychiatric Status Rating Scales
Psychotic Disorders drug therapy
Psychotic Disorders psychology
Medication Adherence psychology
Medication Adherence statistics & numerical data
Antipsychotic Agents therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1433-9285
- Volume :
- 59
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Social psychiatry and psychiatric epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 37833425
- Full Text :
- https://doi.org/10.1007/s00127-023-02563-4