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The many paths to artemisinin resistance in Plasmodium falciparum.

Authors :
Pandit K
Surolia N
Bhattacharjee S
Karmodiya K
Source :
Trends in parasitology [Trends Parasitol] 2023 Dec; Vol. 39 (12), pp. 1060-1073. Date of Electronic Publication: 2023 Oct 11.
Publication Year :
2023

Abstract

Emerging resistance against artemisinin (ART) poses a major challenge in controlling malaria. Parasites with mutations in PfKelch13, the major marker for ART resistance, are known to reduce hemoglobin endocytosis, induce unfolded protein response (UPR), elevate phosphatidylinositol-3-phosphate (PI3P) levels, and stimulate autophagy. Nonetheless, PfKelch13-independent resistance is also reported, indicating extensive complementation by reconfiguration in the parasite metabolome and transcriptome. These findings implicate that there may not be a single 'universal identifier' of ART resistance. This review sheds light on the molecular, transcriptional, and metabolic pathways associated with ART resistance, while also highlighting the interplay between cellular heterogeneity, environmental stress, and ART sensitivity.<br />Competing Interests: Declaration of interests The authors declare no competing interests.<br /> (Copyright © 2023 Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1471-5007
Volume :
39
Issue :
12
Database :
MEDLINE
Journal :
Trends in parasitology
Publication Type :
Academic Journal
Accession number :
37833166
Full Text :
https://doi.org/10.1016/j.pt.2023.09.011