Comparative metabolomics reveal key pathways associated with the synergistic activities of aztreonam and clavulanate combination against multidrug-resistant Escherichia coli .

Authors :: Zhang J
Yang H
Zhang L
Lv Z
Yu M
Sy SKB
Zhan Y
Source :: MSystems [mSystems] 2023 Dec 21; Vol. 8 (6), pp. e0075823. Date of Electronic Publication: 2023 Oct 13.
Publication Year :: 2023
Abstract: Importance: Multidrug-resistant Escherichia coli is a major threat to the health care system and is associated with poor outcomes in infected patients. The combined use of antibiotics has become an important treatment method for multidrug-resistant bacteria. However, the mechanism for their synergism has yet to be explored.<br />Competing Interests: The authors declare no conflict of interest.

Subjects :: Humans
Clavulanic Acid pharmacology
Amoxicillin-Potassium Clavulanate Combination metabolism
beta-Lactamases metabolism
Aztreonam pharmacology
Escherichia coli metabolism

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