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Attenuated Salmonella carrying siRNA-CD24 improved the effect of oxaliplatin on HCC.
- Source :
-
International immunopharmacology [Int Immunopharmacol] 2023 Nov; Vol. 124 (Pt B), pp. 111025. Date of Electronic Publication: 2023 Oct 10. - Publication Year :
- 2023
-
Abstract
- Oxaliplatin is a chemotherapy drug currently utilized in the treatment of advanced cancer patients. However, its tolerability poses a limitation to its clinical application. Studies have demonstrated that the presence of tumor-associated macrophages is positively correlated with poor prognosis in various solid tumors, including hepatocellular carcinoma (HCC), and is a significant factor contributing to oxaliplatin resistance. Therefore, targeting tumor-associated macrophages may be an effective strategy to improve the efficacy of oxaliplatin in the treatment of HCC patients. CD24 is a novel target for tumor therapy that can interact with the inhibitory receptor Siglec-10 on tumor-associated macrophages, transmitting immune inhibitory signals and inhibiting macrophage phagocytosis function. In this study, we utilized RNAi technology to inhibit the expression of CD24 in tumor cells and combined it with oxaliplatin, resulting in reduced tumor invasion, migration, and proliferation, as well as increased cell apoptosis. Furthermore, immunofluorescence and flow cytometry results indicated that both the single treatment group and combination treatment group enhanced the infiltration of immune cells. This study presents a novel approach to identifying combination therapy and targets for the clinical treatment of HCC with oxaliplatin.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2023 Elsevier B.V. All rights reserved.)
- Subjects :
- Humans
Oxaliplatin pharmacology
Oxaliplatin therapeutic use
RNA, Small Interfering genetics
Carrier Proteins
Cell Line, Tumor
CD24 Antigen genetics
CD24 Antigen metabolism
Carcinoma, Hepatocellular drug therapy
Carcinoma, Hepatocellular genetics
Carcinoma, Hepatocellular metabolism
Liver Neoplasms drug therapy
Liver Neoplasms genetics
Liver Neoplasms metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1878-1705
- Volume :
- 124
- Issue :
- Pt B
- Database :
- MEDLINE
- Journal :
- International immunopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 37827056
- Full Text :
- https://doi.org/10.1016/j.intimp.2023.111025