High Variability in Isavuconazole Unbound Fraction in Clinical Practice: A Call to Reconsider Pharmacokinetic/Pharmacodynamic Targets and Breakpoints.

Authors :: Jansen AME
Ter Heine R
Verweij PE
Brüggemann RJM
Source :: Clinical pharmacokinetics [Clin Pharmacokinet] 2023 Dec; Vol. 62 (12), pp. 1695-1699. Date of Electronic Publication: 2023 Oct 11.
Publication Year :: 2023
Abstract: Isavuconazole exposure-response relationships have been studied with a focus on total rather than unbound exposure, assuming a constant unbound fraction of 1%. We observed a median (range) unbound fraction of 1.59% (0.42-5.30%) in patients. This highly variable protein binding asks for re-evaluation of current pharmacokinetic and pharmacodynamic targets for isavuconazole.<br /> (© 2023. The Author(s).)

Subjects :: Humans
Protein Binding
Triazoles pharmacokinetics
Nitriles pharmacokinetics
Pyridines therapeutic use
Pyridines pharmacokinetics

Full Text Access

Tools