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Real-world treatment patterns, healthcare resource utilization and costs among patients with peripheral T-cell lymphoma.
- Source :
-
Future oncology (London, England) [Future Oncol] 2024 May; Vol. 20 (15), pp. 1013-1030. Date of Electronic Publication: 2023 Oct 10. - Publication Year :
- 2024
-
Abstract
- Objective: To evaluate treatment patterns, healthcare resource utilization (HRU) and costs among peripheral T-cell lymphoma (PTCL) patients in the USA. Methods: A retrospective cohort study, using the IQVIA PharMetrics <superscript>®</superscript> Plus claims database from 1 April 2011 to 30 November 2021, identified PTCL patients receiving systemic treatments. Three mutually exclusive subcohorts were created based on line of therapy (LOT): 1LOT, 2LOT and ≥3LOT. Common treatment regimens, median time on treatment, all-cause and PTCL-related HRU and costs were estimated. Results: Among 189 PTCL patients identified, 61.9% had 1LOT, 21.7% had 2LOT and 16.4% had ≥3LOT. The most common treatment regimens in the 1LOT were CHOP/CHOP-like, CHOEP/CHOEP-like and brentuximab vedotin; monotherapies were most common in the 2LOT and ≥3LOT. All-cause and PTCL-related hospitalizations and prescriptions PPPM increased with increasing LOT. Nearly 70% of total treatment costs were PTCL related. Conclusion: Higher utilization of combination therapies in the 1LOT and monotherapies in subsequent LOTs were observed, alongside high PTCL-related costs.
- Subjects :
- Humans
Retrospective Studies
Antineoplastic Combined Chemotherapy Protocols adverse effects
Brentuximab Vedotin therapeutic use
Health Care Costs
Doxorubicin
Cyclophosphamide therapeutic use
Vincristine therapeutic use
Prednisone
Lymphoma, T-Cell, Peripheral drug therapy
Lymphoma, T-Cell, Peripheral epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1744-8301
- Volume :
- 20
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Future oncology (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 37814886
- Full Text :
- https://doi.org/10.2217/fon-2023-0615