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Loganin protects against myocardial ischemia-reperfusion injury by modulating oxidative stress and cellular apoptosis via activation of JAK2/STAT3 signaling.
- Source :
-
International journal of cardiology [Int J Cardiol] 2024 Jan 15; Vol. 395, pp. 131426. Date of Electronic Publication: 2023 Oct 09. - Publication Year :
- 2024
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Abstract
- Background: Myocardial ischemia-reperfusion injury (MIRI) is a pathological process that follows immediate revascularization of myocardial infarction and is characterized by exacerbation of cardiac injury. Loganin, a monoterpene iridoid glycoside derived from Cornus officinalis Sieb. Et Zucc, can exert cardioprotective effects in cardiac hypertrophy and atherosclerosis. However, its role in ischemic heart disease remains largely unknown.<br />Methods: Considering that Janus kinase 2 (JAK2)/ signal transducer and activator of transcription 3 (STAT3) has a protective effect on the heart, we developed a mouse model of MIRI to investigate the potential role of this pathway in loganin-induced cardioprotection.<br />Results: Our results showed that treatment with loganin (20 mg/kg) prevented the enlargement of myocardial infarction, myocyte destruction, serum markers of cardiac injury, and deterioration of cardiac function induced by MIRI. Myocardium subjected to I/R treatment exhibited higher levels of oxidative stress, as indicated by an increase in malondialdehyde (MDA) and dihydroethidium (DHE) density and a decrease in total antioxidant capacity (T-AOC), glutathione (GSH), and superoxide dismutase (SOD), whereas treatment with loganin showed significant attenuation of I/R-induced oxidative stress. Loganin treatment also increased the expression of anti-apoptotic Bcl-2 and reduced the expression of caspase-3/9, Bax, and the number of TUNEL-positive cells in ischemic cardiac tissue. Moreover, treatment with loganin triggered JAK2/STAT3 phosphorylation, and AG490, a JAK2/STAT3 inhibitor, partially abrogated the cardioprotective effects of loganin, indicating the essential role of JAK2/STAT3 signaling in the cardioprotective effects of loganin.<br />Conclusions: Our data demonstrate that loganin protects the heart from I/R injury by inhibiting I/R-induced oxidative stress and cellular apoptosis via activation of JAK2/STAT3 signaling.<br /> (Copyright © 2023 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Mice
Apoptosis drug effects
Janus Kinase 2 drug effects
Janus Kinase 2 metabolism
Myocytes, Cardiac metabolism
Oxidative Stress drug effects
STAT3 Transcription Factor drug effects
STAT3 Transcription Factor metabolism
Myocardial Infarction metabolism
Myocardial Reperfusion Injury prevention & control
Myocardial Reperfusion Injury metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1874-1754
- Volume :
- 395
- Database :
- MEDLINE
- Journal :
- International journal of cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 37813285
- Full Text :
- https://doi.org/10.1016/j.ijcard.2023.131426