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Role of Mitochondrial Dysfunction in Cellular Lipid Homeostasis and Disease.

Authors :
Bathina S
Das UN
Source :
Discovery medicine [Discov Med] 2023 Oct; Vol. 35 (178), pp. 653-663.
Publication Year :
2023

Abstract

Mitochondria-associated membranes (MAMs) play a significant role in multiple cellular processes including lipid metabolism and neuronal survival. Fatty acids constitute 80% of the dry mass of the brain and are vital for life. Apart from mitochondrial β-oxidation, fatty acids are metabolized in part by peroxisomes to regulate the generation of acyl Coenzyme A and adenosine triphosphate (ATP). Ablation of mitochondria and its associated genes tether endoplasmic reticulum (ER)-Mitochondria contact and results in loss of function leading to aberrant lipid metabolism. Additionally, an increase in reactive oxygen species (ROS) levels along with free radicals' generation may lead to alteration in the integrity of membrane phospholipids, proteins, and DNA. Hence, it is critical to understand the effect of structural and functional aspects of mitochondria on lipid homeostasis. This review explains the role of mitochondrial dysfunction in lipid metabolism and its impact on various neurodegenerative diseases and metabolic disorders.

Details

Language :
English
ISSN :
1944-7930
Volume :
35
Issue :
178
Database :
MEDLINE
Journal :
Discovery medicine
Publication Type :
Academic Journal
Accession number :
37811607
Full Text :
https://doi.org/10.24976/Discov.Med.202335178.64