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Clinical presentations and outcomes of young women aged <40 yrs with Ductal carcinoma in situ.
Clinical presentations and outcomes of young women aged <40 yrs with Ductal carcinoma in situ.
- Source :
-
Breast disease [Breast Dis] 2023; Vol. 42 (1), pp. 299-303. - Publication Year :
- 2023
-
Abstract
- Introduction: Ductal carcinoma in situ (DCIS) in young women is rare and not well studied. Since they do not qualify for mammographic screening, they are more likely to present with symptoms. Young women have also been associated with poorer outcomes, but it is unknown whether presentation mode affects outcome. We aimed to compare characteristics of DCIS patients <40 years of age presenting with symptoms versus those without, and determine whether presentation mode affects recurrence.<br />Methods: Pure DCIS patients aged <40 years were retrospectively analyzed. Clinical presentation, pathology and recurrence data were collected. Statistical analysis was performed to investigate the correlation of presentation mode with outcomes.<br />Results: 40 patients with 41 cases were included. The mean age at diagnosis was 32.3 years (range 17-39). 73.2% and 26.8% presented with symptoms or abnormal imaging respectively. Of the cases who presented with symptoms, 86.7%, 10.0% and 3.3% had palpable lump, nipple discharge or breast pain, respectively. The average tumor size was 22.0 mm (range 2.0-86.9) and 12.2 mm (range 3-25) for patients who presented with symptoms and non-symptomatic group, respectively. Cases presenting with symptoms were statistically associated with higher grade (p = 0.0090). On median follow-up of 85 months, there were 3 (7.3%) recurrences, which were not statistically associated with presentation mode.<br />Conclusion: Young women with DCIS tend to present with symptoms, with breast lump as the commonest symptom. Symptomatic patients tend to be associated with grade III tumours, compared to non-symptomatic patients. On long-term follow-up, mode of presentation was not statistically associated with recurrence.
- Subjects :
- Humans
Female
Adolescent
Young Adult
Adult
Retrospective Studies
Follow-Up Studies
Breast pathology
Neoplasm Recurrence, Local
Carcinoma, Intraductal, Noninfiltrating diagnosis
Carcinoma, Intraductal, Noninfiltrating therapy
Carcinoma, Intraductal, Noninfiltrating pathology
Breast Neoplasms
Carcinoma, Ductal, Breast pathology
Carcinoma in Situ pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1558-1551
- Volume :
- 42
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Breast disease
- Publication Type :
- Academic Journal
- Accession number :
- 37807772
- Full Text :
- https://doi.org/10.3233/BD-230018