Deconstructing the integrated oscillator model for pancreatic β-cells.

Authors :: Bertram R
Marinelli I
Fletcher PA
Satin LS
Sherman AS
Source :: Mathematical biosciences [Math Biosci] 2023 Nov; Vol. 365, pp. 109085. Date of Electronic Publication: 2023 Oct 04.
Publication Year :: 2023
Abstract: Electrical bursting oscillations in the β-cells of pancreatic islets have been a focus of investigation for more than fifty years. This has been aided by mathematical models, which are descendants of the pioneering Chay-Keizer model. This article describes the key biophysical and mathematical elements of this model, and then describes the path forward from there to the Integrated Oscillator Model (IOM). It is both a history and a deconstruction of the IOM that describes the various elements that have been added to the model over time, and the motivation for adding them. Finally, the article is a celebration of the 40th anniversary of the publication of the Chay-Keizer model.<br />Competing Interests: Declaration of competing interest None.<br /> (Copyright © 2023. Published by Elsevier Inc.)