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The effect of hydrogen-rich water on letrozole-induced polycystic ovary syndrome in rats.
- Source :
-
Reproductive biomedicine online [Reprod Biomed Online] 2023 Dec; Vol. 47 (6), pp. 103332. Date of Electronic Publication: 2023 Aug 06. - Publication Year :
- 2023
-
Abstract
- Research Question: What is the effect of hydrogen-rich water on rats with polycystic ovary syndrome (PCOS)?<br />Design: Female rats were divided into four groups, each consisting of eight animals. The control group received a carboxymethyl cellulose (CMC) solution, the molecular hydrogen (H2) group was given hydrogen-rich water and a CMC solution, the PCOS group was administered letrozole dissolved in a CMC solution and the PCOS + H2 group was given hydrogen-rich water and letrozole dissolved in a CMC solution. Blood and tissue samples were then collected, and biochemical and histopathological analyses were conducted on the samples.<br />Results: The histopathological analysis showed a reduction in the number of cysts in the PCOS + H2 group compared with the PCOS group (P < 0.0001). Additionally, the malondialdehyde, cortisol and testosterone data revealed a significant decrease in the PCOS + H2 group compared with the PCOS group (P = 0.0458, P = 0.0003, P = 0.0041, respectively). The glutathione also showed a statistically significant increase in the PCOS + H2 group compared with the PCOS group (P = 0.0012).<br />Conclusion: The study findings demonstrate that hydrogen-rich water reduces the number of cysts and oxidative damage in rats with PCOS.<br /> (Copyright © 2023 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1472-6491
- Volume :
- 47
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Reproductive biomedicine online
- Publication Type :
- Academic Journal
- Accession number :
- 37797471
- Full Text :
- https://doi.org/10.1016/j.rbmo.2023.103332