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Mapping SARS-CoV-2 antigenic relationships and serological responses.
- Source :
-
Science (New York, N.Y.) [Science] 2023 Oct 06; Vol. 382 (6666), pp. eadj0070. Date of Electronic Publication: 2023 Oct 06. - Publication Year :
- 2023
-
Abstract
- During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, multiple variants escaping preexisting immunity emerged, causing reinfections of previously exposed individuals. Here, we used antigenic cartography to analyze patterns of cross-reactivity among 21 variants and 15 groups of human sera obtained after primary infection with 10 different variants or after messenger RNA (mRNA)-1273 or mRNA-1273.351 vaccination. We found antigenic differences among pre-Omicron variants caused by substitutions at spike-protein positions 417, 452, 484, and 501. Quantifying changes in response breadth over time and with additional vaccine doses, our results show the largest increase between 4 weeks and >3 months after a second dose. We found changes in immunodominance of different spike regions, depending on the variant an individual was first exposed to, with implications for variant risk assessment and vaccine-strain selection.
- Subjects :
- Humans
Antibodies, Neutralizing blood
Antibodies, Neutralizing immunology
Antibodies, Viral blood
Antibodies, Viral immunology
Cross Reactions
Vaccination
Amino Acid Substitution
COVID-19
SARS-CoV-2 genetics
SARS-CoV-2 immunology
Spike Glycoprotein, Coronavirus genetics
Spike Glycoprotein, Coronavirus immunology
Antigens, Viral genetics
Antigens, Viral immunology
mRNA Vaccines immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9203
- Volume :
- 382
- Issue :
- 6666
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 37797027
- Full Text :
- https://doi.org/10.1126/science.adj0070