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Fetal surgery using fetoscopic endoluminal tracheal occlusion for severe congenital diaphragmatic hernia: a single-center experience.
- Source :
-
Archives of gynecology and obstetrics [Arch Gynecol Obstet] 2024 Jul; Vol. 310 (1), pp. 345-351. Date of Electronic Publication: 2023 Oct 03. - Publication Year :
- 2024
-
Abstract
- Purpose: To provide a comprehensive report of the experience gained in the prenatal treatment of congenital diaphragmatic hernia (CDH) using fetoscopic endoluminal tracheal occlusion (FETO) following its implementation at a newly established specialized fetal medicine center.<br />Methods: Mothers of fetuses with severe CDH were offered prenatal treatment by FETO.<br />Results: Between 2018 and 2021, 16 cases of severe CDH underwent FETO. The median gestational age (GA) at balloon insertion was 28.4 weeks (IQR 27.8-28.6). The median GA at delivery was 37 weeks (IQR 34.4-37.8). The survival rate was 8/16 cases (50%). None of the survivors required home oxygen therapy at 6 months of age. Comparison between the survivors and deceased showed that survivors had balloon insertion 1 week earlier (27.8 vs. 28.4 weeks, p = 0.007), a higher amniotic fluid level change between pre- to post-FETO (3.4 vs 1.3, p = 0.024), a higher O/E LHR change between pre- to post-FETO (50.8 vs. 37.5, p = 0.047), and a GA at delivery that was 2 weeks later (37.6 vs. 35.4 weeks, p = 0.032).<br />Conclusions: The survival rate at 6 months of age in cases of severe CDH treated with FETO in our center was 50%. Our new fetal medicine center matches the performance of other leading international centers.<br /> (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Details
- Language :
- English
- ISSN :
- 1432-0711
- Volume :
- 310
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Archives of gynecology and obstetrics
- Publication Type :
- Academic Journal
- Accession number :
- 37789206
- Full Text :
- https://doi.org/10.1007/s00404-023-07215-1